THE MADNESS PILL: One Doctor's Quest to Understand Schizophrenia, can be a tough read but has a hopeful ending

THE MADNESS PILL: One Doctor's Quest to Understand Schizophrenia
JUSTIN GARSON
St. Martin's Press (non-affiliate Bookshop.org link)
$15.99 ebook, available now

Rating: 4.5* of five

The Publisher Says: A rollicking history of the life and work of an unheralded genius: Dr. Solomon Snyder, whose experiments with mind-altering drugs helped change the way we think about the causes and treatments of schizophrenia.

In the 1950s, the field of psychiatry had nothing to show for itself. While polio was being cured, antibiotics were being discovered, and cancer research was developing, the mental health world had no wins. Asylums were full and nobody had figured out how to fix insanity—specifically schizophrenia, the severest mental illness. Scientists became convinced that if they could engineer a pill to create madness, then they could cure it.

Centered around Solomon Snyder, the psychiatrist who ultimately did identify the madness pill, and the community of doctors and researchers he worked with, THE MADNESS PILL recounts the drug-fueled quest to cure schizophrenia. A wunderkind who started medical school at 19, Snyder worked steadily for decades to replicate the illness, ultimately finding in 1970 that amphetamines could trigger a schizophrenia-like state by flooding the brain with dopamine. Five years later, he went on to discover the dopamine receptor and proved that antipsychotic drugs work by disabling dopamine neurons. Snyder’s dopamine hypothesis inspired a generation of researchers to part ways with psychoanalysis and look for the biological basis of schizophrenia and other mental disorders.

Using first-hand research and interviews, THE MADNESS PILL is at once a raucous history and insightful portrait of a remarkable scientist who turned psychiatry into a respected science by transforming how mental illness is treated.

I RECEIVED A DRC FROM THE PUBLISHER VIA NETGALLEY. THANK YOU.

My Review: I did not think I'd review this book all that politely. The publicists who wrote the synopsis above used two words in particular that felt...off, odd, even a smidge dishonest, in my mental ear: "rollicking" and "raucous." A scientist's life's work decribed in storytelling superlatives, not scientific ones like "groundbreaking" or "paradigm-shifting"? ::side-eye::

One victory for y'all, publicists. This story as told by Author Garson does indeed rollick raucously through Solomon Snyder's life's work in neurochemistry. I'm a big proponent of talk therapy for those able to benefit from it. Those who can benefit include me (happily) when, after a major crisis that was stabilized by antidepressants, aka neurochemicals, I entered another phase of talk therapy that has presented me with ongoing benefits that I remain deeply grateful for.

Schizoaffective disorder and the multitude of brain-chemistry malfunctions related to it is not adequately addressed by talk therapy. Until Solomon Snyder got to pokin' around because there was zero progress towards curing this life-ruining disorder, there was no good outcome for its sufferers on offer anywhere. It's still a horrendously difficult condition to manage even with neurochemical models explaining some root causes of its symptoms, and chemical therapies helping manage some of devastatingly painful results of its symptoms.

Author Garson is chatty in his presentation of the facts uncovered by Sol, as Dr. Snyder seems to be universally referred to after a time, and his collaborators and even enemies. (No one who changes paradigms is going to be without enemies, detractors, and ill-wishers.) The chattiness and the organizing principle of Sol's personality and perspicacity leads to the strange sense that we're getting to know *about* Sol, getting to know how he affected people and worked with them...or didn't...but not to *know* him. The research, the systems of conducting it, aren't glossed over or lingered on. It's very uncomfortable stuff to our twenty-first century eyes. Sol was in the thick of it. He did wonders for people who previously had little to hope for; getting there, he caused harm and suffering. Those who suffer with experimental animals are strongly cautioned not to read this story; those who feel raw about issues of consent are not going to find this subject matter at all easy to contend with.

There truly is no light without shadow.

Light there is, all in despite of the dark tunnel traversed to get to it. I have known eople suffering with schizophrenia who, when medicated, felt worlds better than without these hard-won treatments. Some have not felt the positive effects outweigh the frustrations of the side-effects that come from altering one's brain chemistry long term. My sample size might not be huge but is exactly in line with the results reported, and analyzed, in Author Garson's story. The names of the chemicals, the names of the drugs, the explication of the functions of them...all of that's a lot, and be ready to use Google often. But the reason to keep your attention on the page is that this detailed information is the foundation of the genuine miracle that is the help offered to previously unhelpable sufferers.

I was so buoyed up by this end result that I was able to consider the abusive and unethical (by today's standards) actions committed and/or not opposed at any point in the process as distasteful, but not disqualifying of the results as very much positive. I do not feel that way about, say, watching a Weinstein-produced film now that I know the crimes he committed, or the awfulness of that transphobic conversion-therapy supporter whose wizard books I once enjoyed.

I offer my ethical calibration for your reference only. Your decision about learning the good with the unpleasant in search of help for the mentally ill is not for me to do more than inform. I felt all the way through the read that I'd've been even happier had Author Garson discussed ethics in specific and open terms as we went along but the way he chose to address the issues passed my muster. Barely...more would've been better.

Again I strongly caution those sensitive to animal suffering to avoid this entire topic. It will not reward you commensurate with your own distress.